From Macomb: Starting at the intersection of West Jackson (US-136) and Wigwam Hollow Road (which has a Casey’s gas station on the corner) drive west on US-136/336 approximately 11 miles and turn south (left) on IL-61 and proceed about 9 miles to Plymouth. When the highway makes a left hand curve in town to the south, turn west (right) at the corner where Ma & Pa’s Cafe is located. Go 4 blocks west on Summer Street to 201 West Summer Street. There is a sign in the front yard by the driveway in which you may park.
From St. Louis Lambert Airport: Go west on I-70 to Wentzville, MO. and turn north (right) on US-61 to Hannibal, MO. At the intersection of US-61 and US-36, turn east (right) on US-36 and cross the Mississippi River into Illinois. Bear to the left off US-36 onto I-172 and go north toward Quincy, IL. I-172 becomes 336 and you will continue on it to the end of the 4-lane which becomes IL-336. Two miles from the end of the four lane there will be a sign to Denver on county road 650 N where you will turn east (right). Plymouth is approximately 11 miles east of IL-336. Turn south (right) on to Lexington Street (by the Methodist Church) and go one block to Plymouth Rock Roost. There is a sign in the front yard and you may park in the front driveway. It is approximately 160 miles from the airport to Plymouth and is all 4-lane except the last 12 miles.
From Carthage: At the east edge of Carthage on US-136 turn south (right) onto IL-336 and proceed approximately 9 miles to county road 650 N (marked with a sign saying Denver and Plymouth and turn east (left). Plymouth is approximately 11 miles east of IL-336. Turn south (right) on to Lexington Street (by the Methodist Church) and go one block to Plymouth Rock Roost. There is a sign in the front yard and you may park in the front driveway.
From Plymouth to Nauvoo: Go west on county road 650 N about 11 miles to IL-336. Turn north (right) on IL-336 about 9 miles to US-136 at Carthage. Turn west (left) on US-136 about 12 miles to Hamilton and turn north (right) on IL-96 for about 11 miles to Nauvoo. The drive from Hamilton to Nauvoo follows the Mississippi River, which is over a mile wide in that area. It has several scenic roadside parks to pull off and enjoy the view of the river and the waterfowl. It is one of the most scenic drives in Illinois.